Physical-chemical tests – Labfit

Physical-chemical tests

Pharmaceutical characterisation of raw materials and formulations

– Organoleptic characteristics (Internal Method);

– Texturometry (Internal Method);

– Viscosity, needle viscometer (European Pharmacopoeia);

– Viscosity, cone and plate viscometer – rheometer (European Pharmacopoeia);

– Osmolality (Internal Method);

– Buffer capacity (Internal Method);

– Dissolution of solid pharmaceutical forms;

– Dosage and identification of compounds by HPLC and GC-MS (preservatives, colourings, nitrosamines, pesticides);

– Disintegration of tablets and capsules;

– Determination of pH;

– Determination of dry extract;

– Determination of refractive index;

– Determination of water activity;

– Determination of alcohol content (using alcoholometer or FTIR);

– Determination of melting point;

– Determination of water content (Karl Fischer volumetric titration);

– Determination of surface tension;

– Wetting power;

– Surfactant power and cleaning action;

– Foam formation and stability;

– Solubility;

– Determination of antioxidant capacity by DPPH reduction

Physical-Chemical Methods

– Hydroxyl Index (European Pharmacopoeia);

– Peroxide Index (European Pharmacopoeia);

– Saponification Index (European Pharmacopoeia);

– Unsaponifiable Matter Content (European Pharmacopoeia);

– Iodine Index (European Pharmacopoeia);

– Hydrogen Peroxide Dosage (Volumetry/Internal Method);

– Cyanide Dosage (Molecular Absorption Spectrophotometry/Internal Method);

– Determination of active chlorine content;

– Determination of Nitrates and Heavy Metals in purified water;

– NaCl content in physiological saline solution;

– Sodium bicarbonate dosage;

– Determination of cationic activity of quaternary compounds;

– Determination of Silica (molecular absorption spectrophotometry);

– Determination of phosphorus (molecular absorption spectrophotometry);

– Determination of alkalinity or acidity in petroleum jelly and soaps;

– Dosage of glycerol in soaps;

– Determination of iron (molecular absorption spectrophotometry);

– Quantification of formaldehyde (colorimetry);

– Determination of free iodine content;

– Dosage of total phenols (Folin-Ciocalteu method);

– Determination of free alkalinity in sodium hypochlorite;

– Dosage of sulphur dioxide (European Pharmacopoeia);

– Dosage of fatty acids in soaps.

Analytical methods

– Dosage of preservatives (HPLC-DAD/Internal Method);

– Dosage of sunscreens (HPLC-DAD/Internal Method);

– Development and validation of analytical methods for the quantification of substances (HPLC-DAD, LC-MS, GC-MS), according to the International Conference Harmonisation (ICH);

– Support for the implementation of analytical methods for the detection and quantification of compounds, according to the ICH;

– Dosage of active ingredients (GC-MS, HPLC-DAD, FTIR, Atomic Absorption);

– Characterisation by FTIR spectroscopy.