Chemical characterization

Chemical characterization of raw materials and formulations

- Organoleptic characteristics (Internal Method)
- Texturometry (Internal Method)
- Viscosity, needle viscometer (European Pharmacopoeia)
- Viscosity, cone and plate viscometer & rheometer (European Pharmacopoeia)
- Osmolality (Internal Method)
- Buffer capacity (Internal Method)
- Dissolution of solid dosage forms
- Dosing and identification of compounds by HPLC and GC-MS (preservatives, dyes, nitrosamines, pesticides)
- Disintegration of tablets and capsules
- pH determination
- Determination of Dry Extract
- Determination of the Refractive Index
- Determination of water activity
- Determination of alcohol content (through Alcoholometer or FTIR)
- Determination of the melting point
- Determination of water content (Karl Fischer volumetric titration)
- Determination of surface tension
- Wetting power
- Surfing power and cleansing action
- Foaming and its stability
- Solubility
- Determination of antioxidant capacity by reducing DPPH

Physical-Chemical Methods

- Acid Index (European Pharmacopoeia)
- Hydroxyl Index (European Pharmacopoeia)
- Peroxide Index (European Pharmacopoeia)
- Saponification Index (European Pharmacopoeia)
- Content of unsaponifiable matter (European Pharmacopoeia)
- Iodine Index (European Pharmacopoeia)
- Hydrogen peroxide measurement (Volumetry / Internal Method)
- Cyanide assay (Spectrophotometry - Molecular Absorption / Internal Method)
- Determination of the active chlorine content
- Determination of Nitrates and Heavy Metals in purified water
- NaCl content in saline
- Dosing of sodium bicarbonate
- Determination of the cationic activity of quaternary compounds
- Determination of Silica (molecular absorption spectrophotometry)
- Determination of Phosphorus (molecular absorption spectrophotometry)
- Determination of Alkalinity or Acidity in petroleum jelly and soaps
- Dosing of glycerol in soaps
- Iron determination (molecular absorption spectrophotometry)
- Quantification of formaldehyde (colorimetry)
- Determination of free iodine content
- Determination of total phenols (Folin-Ciocalteu method)
- Determination of Free Alkalinity in Sodium Hypochlorite
- Sulfur dioxide measurement (European Pharmacopoeia)
- Dosing of fat acids in soaps

 

Analytical methods

- Dosing of preservatives (HPLC-DAD / Internal Method)
- Dosing sunscreens (HPLC-DAD / Internal Method)
- Development and validation of analytical methods for quantifying substances (HPLC-DAD, LC-MS, GC-MS), according to the International Conference Harmonization (ICH)
- Support for the implementation of analytical methods for detection and quantification of compounds, according to ICH
- Asset dosing (GC-MS, HPLC-DAD, FTIR, Atomic absorption)
- Characterization by FTIR spectroscopy